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Lecture

Morphogenetically active amorphous polyphosphate: A multifunctional bioinspired material for customized and regenerative medicine

Wednesday (18.03.2020)
08:30 - 08:50
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INORGANIC POLYPHOSPHATE (POLYP) IS ONE OF THE OLDEST CHEMICAL ENERGY-PROVIDING MOLECULES IN BIOLOGICAL SYSTEMS. THIS POLYMER, CONTAINING A MUCH LONGER SEQUENCE OF HIGH-ENERGY PHOSPHATE UNITS THAN THE UNIVERSAL ENERGY DONOR ADENOSINE TRIPHOSPHATE (ATP), HAS ATTRACTED INCREASING ATTENTION FOR POTENTIAL BIOMEDICAL APPLICATIONS BECAUSE OF ITS DIVERSE METABOLIC AND REGULATORY FUNCTIONS AND ITS ABILITY TO FORM BIOLOGICALLY ACTIVE NANO/MICROPARTICLES.

THE ABILITY TO STORE AND PROVIDE METABOLIC ENERGY IS IMPORTANT ESPECIALLY FOR REGENERATION OF BRADYTROPHIC TISSUES LACKING ANY VASCULARIZATION, LIKE CARTILAGE, BUT ALSO FOR OTHER ENERGY CONSUMING PROCESSES LIKE WOUND HEALING. THIS ENERGY IS REQUIRED NOT ONLY FOR CELL GROWTH AND FUNCTION BUT ALSO FOR THE FORMATION/MAINTENANCE OF THE EXTRACELLULAR SUPRAMOLECULAR ARCHITECTURE (ECM). POLYP CAN BE PROVIDED EITHER AS PARTICLES, WHICH ARE STABLE AND CAN BE STORED OVER PROLONGED TIME PERIODS, OR AS A SOLUBLE SALT.

IN ITS PARTICULATE FORM, POLYP IS NOT BIOLOGICALLY ACTIVE BUT THESE PARTICLES EASILY TRANSFORM INTO A COACERVATE FORM IN WHICH POLYP IS BIOLOGICALLY ACTIVE. POLYP CAN BE EASILY COMBINED WITH OTHER MATERIALS USED IN TISSUE ENGINEERING, E.G. FOR THE PRODUCTION OF BIOPRINTABLE BIOINKS (EVEN FOR CELL PRINTING) OR STABLE POLYMERS SUCH AS POLYMETHACRYLATE OF POLYCAPROLACTONE. IN THIS WAY, THE MATERIAL COULD BE APPLIED NOT ONLY AS A FILLER, BUT ALSO FOR THE FABRICATION OF LARGER MECHANICALLY MORE STABLE IMPLANTS. IN ADDITION, TOGETHER WITH OTHER NEGATIVE POLYANIONS, POLYP IS ABLE TO SELF-ORGANIZE THE PRESENCE OF DIVALENT CATIONS TO POLYMER BUNDLES STABILIZED BY CA2+ BRIDGES, OR POLYP NANO/MICROPARTICLES CAN BE CREATED IN SITU FROM POLYP INCORPORATED INTO CERTAIN HYDROGELS. THROUGH THE SELECTION OF SUITABLE HYDROGEL-FORMING POLYMERS AND CONTROLLED HARDENING VIA CALCIUM IONS, HYBRID BIOMATERIALS OF DEFINED POROSITY AND MECHANICAL PROPERTIES CAN BE FABRICATED, WHICH ARE NOT ONLY MORPHOGENETICALLY ACTIVE, BUT ALSO PROVIDE THE CELLS WITH THE ENERGY NEEDED FOR THEIR FUNCTION, INCLUDING THOSE PROCESSES WHICH PROCEED IN THE EXTRACELLULAR SPACE.

WITH THE DISCOVERY OF POLYP AND THE CHARACTERIZATION OF THE MULTIPLE FUNCTIONS OF THIS ENERGY-RICH BIOPOLYMER, A NEW PHYSIOLOGICAL MOLECULE HAS BEEN INTRODUCED INTO THE GROWING GROUP OF BIOINSPIRED MATERIALS for customized and regenerative medicINE. THERE IS NO OTHER BIOMATERIAL THAT IS PROVIDED WITH THIS PROPERTY COMBINATION.

Speaker:
Prof. Dr. Werner E.G. Müller
University Medical Center of the Johannes Gutenberg University Mainz
Additional Authors:
  • Prof. Dr. Xiaohong Wang
    University Medical Center of the Johannes Gutenberg University Mainz