Programme

Unfurtunately the monastery Irsee has been closed by the Bavarian government due to the corona virus.

Therefore we have decided to offer the conference as a web conference only.

In those unpredictable times, protecting our participants’ health has the highest priority for us!

The scientific exchange must not come to a complete standstill and we believe that with this web solution we have found a way to keep the scientific community going.

In order to participate in the livestream of the conference as easy as possible and to give your presentation, we recommend the use of the web browsers Google Chrome or Microsoft Edge.

Here you can find detailed instructions for using the livestream.

As a participant of the Bioinspired 2020 you have received an e-mail containing the login data for the web conference.

The login data for the sessions are provided daily.

In order to allow all conference participants access to the posters, we ask you to upload your poster by login on the conference homepage and clicking on the button "My Submission" in the upper right corner of the conference homepage. Then select the submission to which you want to upload the poster and upload the poster at the bottom of the page.

Furthermore we would like to ask all poster authors to prepare 4 PowerPoint slides to present your poster to the audience.
Please also include your contact details on the digital poster to allow participants to reach you with questions.

Please note that your poster will be pictured publically.

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Click on "My Submissions" in the upper right corner at the homepage.

Poster documents can be found by opening the respective abstract in the online programme.
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Back to overview

Lecture

Morphogenetically active amorphous polyphosphate: A multifunctional bioinspired material for customized and regenerative medicine

Wednesday (18.03.2020)
08:30 - 08:50

INORGANIC POLYPHOSPHATE (POLYP) IS ONE OF THE OLDEST CHEMICAL ENERGY-PROVIDING MOLECULES IN BIOLOGICAL SYSTEMS. THIS POLYMER, CONTAINING A MUCH LONGER SEQUENCE OF HIGH-ENERGY PHOSPHATE UNITS THAN THE UNIVERSAL ENERGY DONOR ADENOSINE TRIPHOSPHATE (ATP), HAS ATTRACTED INCREASING ATTENTION FOR POTENTIAL BIOMEDICAL APPLICATIONS BECAUSE OF ITS DIVERSE METABOLIC AND REGULATORY FUNCTIONS AND ITS ABILITY TO FORM BIOLOGICALLY ACTIVE NANO/MICROPARTICLES.

THE ABILITY TO STORE AND PROVIDE METABOLIC ENERGY IS IMPORTANT ESPECIALLY FOR REGENERATION OF BRADYTROPHIC TISSUES LACKING ANY VASCULARIZATION, LIKE CARTILAGE, BUT ALSO FOR OTHER ENERGY CONSUMING PROCESSES LIKE WOUND HEALING. THIS ENERGY IS REQUIRED NOT ONLY FOR CELL GROWTH AND FUNCTION BUT ALSO FOR THE FORMATION/MAINTENANCE OF THE EXTRACELLULAR SUPRAMOLECULAR ARCHITECTURE (ECM). POLYP CAN BE PROVIDED EITHER AS PARTICLES, WHICH ARE STABLE AND CAN BE STORED OVER PROLONGED TIME PERIODS, OR AS A SOLUBLE SALT.

IN ITS PARTICULATE FORM, POLYP IS NOT BIOLOGICALLY ACTIVE BUT THESE PARTICLES EASILY TRANSFORM INTO A COACERVATE FORM IN WHICH POLYP IS BIOLOGICALLY ACTIVE. POLYP CAN BE EASILY COMBINED WITH OTHER MATERIALS USED IN TISSUE ENGINEERING, E.G. FOR THE PRODUCTION OF BIOPRINTABLE BIOINKS (EVEN FOR CELL PRINTING) OR STABLE POLYMERS SUCH AS POLYMETHACRYLATE OF POLYCAPROLACTONE. IN THIS WAY, THE MATERIAL COULD BE APPLIED NOT ONLY AS A FILLER, BUT ALSO FOR THE FABRICATION OF LARGER MECHANICALLY MORE STABLE IMPLANTS. IN ADDITION, TOGETHER WITH OTHER NEGATIVE POLYANIONS, POLYP IS ABLE TO SELF-ORGANIZE THE PRESENCE OF DIVALENT CATIONS TO POLYMER BUNDLES STABILIZED BY CA2+ BRIDGES, OR POLYP NANO/MICROPARTICLES CAN BE CREATED IN SITU FROM POLYP INCORPORATED INTO CERTAIN HYDROGELS. THROUGH THE SELECTION OF SUITABLE HYDROGEL-FORMING POLYMERS AND CONTROLLED HARDENING VIA CALCIUM IONS, HYBRID BIOMATERIALS OF DEFINED POROSITY AND MECHANICAL PROPERTIES CAN BE FABRICATED, WHICH ARE NOT ONLY MORPHOGENETICALLY ACTIVE, BUT ALSO PROVIDE THE CELLS WITH THE ENERGY NEEDED FOR THEIR FUNCTION, INCLUDING THOSE PROCESSES WHICH PROCEED IN THE EXTRACELLULAR SPACE.

WITH THE DISCOVERY OF POLYP AND THE CHARACTERIZATION OF THE MULTIPLE FUNCTIONS OF THIS ENERGY-RICH BIOPOLYMER, A NEW PHYSIOLOGICAL MOLECULE HAS BEEN INTRODUCED INTO THE GROWING GROUP OF BIOINSPIRED MATERIALS for customized and regenerative medicINE. THERE IS NO OTHER BIOMATERIAL THAT IS PROVIDED WITH THIS PROPERTY COMBINATION.

Speaker:
Prof. Dr. Werner E.G. Müller
University Medical Center of the Johannes Gutenberg University Mainz
Additional Authors:
  • Prof. Dr. Xiaohong Wang
    University Medical Center of the Johannes Gutenberg University Mainz