Programme

Unfurtunately the monastery Irsee has been closed by the Bavarian government due to the corona virus.

Therefore we have decided to offer the conference as a web conference only.

In those unpredictable times, protecting our participants’ health has the highest priority for us!

The scientific exchange must not come to a complete standstill and we believe that with this web solution we have found a way to keep the scientific community going.

In order to participate in the livestream of the conference as easy as possible and to give your presentation, we recommend the use of the web browsers Google Chrome or Microsoft Edge.

Here you can find detailed instructions for using the livestream.

As a participant of the Bioinspired 2020 you have received an e-mail containing the login data for the web conference.

The login data for the sessions are provided daily.

In order to allow all conference participants access to the posters, we ask you to upload your poster by login on the conference homepage and clicking on the button "My Submission" in the upper right corner of the conference homepage. Then select the submission to which you want to upload the poster and upload the poster at the bottom of the page.

Furthermore we would like to ask all poster authors to prepare 4 PowerPoint slides to present your poster to the audience.
Please also include your contact details on the digital poster to allow participants to reach you with questions.

Please note that your poster will be pictured publically.

As poster author you can upload your poster similar to the way you submitted your abstract.
Click on "My Submissions" in the upper right corner at the homepage.

Poster documents can be found by opening the respective abstract in the online programme.
If a poster document has already been uploaded for the abstract, it can then be opened and downloaded.

Please note that your poster will be pictured publically.

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Please use for this the Q&A (F&A) button!

For further scientific exchange we implemented a discussion forum on the homepage of the DGM.
Please visit discussion.dgm.de and use your DGM or Bioinspired user credentials to login.

Back to overview

Poster with short presentation

Spider Silk - Based Carrier for Controlled Redox- and pH-Triggered Drug Release

Monday (16.03.2020)
17:35 - 17:38

Targeted drug delivery and controlled drug release depend on specific polymers. Polymer nanoparticles are therefore typically used for encapsulation or as matrix for coupling or adhesion of drug molecules. [1] Due to their biocompatibility, biodegradability and possibility of functionalization, particles made of recombinant spider silk proteins are promising candidates for such applications. [2] They have previously been confirmed as suitable drug and gene carrier. Various drug substances or biologicals could be loaded, and steady release was observed over a defined period. [3, 4] However, the release of loaded substances could not be controlled spatio-temporally, since they were bound non-covalently via charge-charge or hydrophobic interactions. Here, we extended the nanoparticles platform made of recombinant spider silk proteins. We present chemically and genetically modified variants of the spider silk protein eADF4(C16) facilitating a triggered release upon physiological changes in pH or redox state. Chemical modification of the proteins’ carboxyl groups with a hydrazone linker followed by coupling of model drugs led to a pH-responsive carrier system, while coupling of model drugs to cysteine containing variants via disulfide bonds resulted in carriers for a redox-responsive release. Release was quantified UV-Vis spectroscopically and additionally, cell culture experiments were performed using fluorescent-labeled compounds confirming intracellular release.

Speaker:
Annika Döbl
University of Bayreuth
Additional Authors:
  • Heike M. Herold
    University of Bayreuth
  • Dr. Stefanie Wohlrab
    University of Bayreuth
  • Dr. Martin Humenik
    University of Bayreuth
  • Prof. Dr. Thomas Scheibel
    University of Bayreuth