Programme

Unfurtunately the monastery Irsee has been closed by the Bavarian government due to the corona virus.

Therefore we have decided to offer the conference as a web conference only.

In those unpredictable times, protecting our participants’ health has the highest priority for us!

The scientific exchange must not come to a complete standstill and we believe that with this web solution we have found a way to keep the scientific community going.

In order to participate in the livestream of the conference as easy as possible and to give your presentation, we recommend the use of the web browsers Google Chrome or Microsoft Edge.

Here you can find detailed instructions for using the livestream.

As a participant of the Bioinspired 2020 you have received an e-mail containing the login data for the web conference.

The login data for the sessions are provided daily.

In order to allow all conference participants access to the posters, we ask you to upload your poster by login on the conference homepage and clicking on the button "My Submission" in the upper right corner of the conference homepage. Then select the submission to which you want to upload the poster and upload the poster at the bottom of the page.

Furthermore we would like to ask all poster authors to prepare 4 PowerPoint slides to present your poster to the audience.
Please also include your contact details on the digital poster to allow participants to reach you with questions.

Please note that your poster will be pictured publically.

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Click on "My Submissions" in the upper right corner at the homepage.

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Back to overview

Poster Pitch

Alteration of human bone mineralization in a sclerosing osteosarcoma

Monday (16.03.2020)
17:23 - 17:26

Osteosarcoma is the most common primary bone cancer type in humans. It is predominantly found in young individuals, with a second peak later in life. The tumour is formed by malignant osteoblasts and consists of collagenous, sometimes also mineralized, bone matrix. While the morphology of osteosarcoma has been well studied, there is virtually no information about the nanostructure of the tumour and changes in mineralization on the nanoscale level. We have studied human bone tissue inside, next to and remote from a sclerosing osteosarcoma with small angle x-ray scattering, x-ray diffraction and electron microscopy. Quantitative evaluation of nanostructure parameters was combined with high resolution, large area mapping to obtain microscopic images with nanostructure parameter contrast. It was found that the tumour regions were characterized by a notable reduction in mineral particle size, while the mineral content was even higher than that in normal bone. Furthermore, the normal preferential orientation of mineral particles along the longitudinal direction of corticalis or trabeculae was largely suppressed. Also the bone mineral crystal structure was affected: severe crystal lattice distortions were detected in mineralized tumour tissue pointing to a different ion substitution of hydroxyl apatite in tumorous tissue than in healthy tissue.


 

Speaker:
Dipl.-Ing. Benjamin Zanghellini
University of Natural Resources and Life Sciences
Additional Authors:
  • Dr. Tilman Gruenewald
    Institut Fresnel
  • Dr. Manfred Burghammer
    European Synchrotron Radiation Facility
  • Dr. Harald Rennhofer
    University of Natural Resources and Life Sciences
  • Dr. Bernadette Liegl-Atzwanger
    Medical University of Graz
  • Dr. Andreas Leithner
    Medical University of Graz
  • Dr. Helga Lichtenegger
    University of Natural Resources and Life Sciences

Dateien

Category Short file description File description File Size
Poster nanostructure of a sclerosing osteosarcoma 5 MB Download