Programme

Unfurtunately the monastery Irsee has been closed by the Bavarian government due to the corona virus.

Therefore we have decided to offer the conference as a web conference only.

In those unpredictable times, protecting our participants’ health has the highest priority for us!

The scientific exchange must not come to a complete standstill and we believe that with this web solution we have found a way to keep the scientific community going.

In order to participate in the livestream of the conference as easy as possible and to give your presentation, we recommend the use of the web browsers Google Chrome or Microsoft Edge.

Here you can find detailed instructions for using the livestream.

As a participant of the Bioinspired 2020 you have received an e-mail containing the login data for the web conference.

The login data for the sessions are provided daily.

In order to allow all conference participants access to the posters, we ask you to upload your poster by login on the conference homepage and clicking on the button "My Submission" in the upper right corner of the conference homepage. Then select the submission to which you want to upload the poster and upload the poster at the bottom of the page.

Furthermore we would like to ask all poster authors to prepare 4 PowerPoint slides to present your poster to the audience.
Please also include your contact details on the digital poster to allow participants to reach you with questions.

Please note that your poster will be pictured publically.

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Click on "My Submissions" in the upper right corner at the homepage.

Poster documents can be found by opening the respective abstract in the online programme.
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Back to overview

Special Poster Session Biofabrication

Hydrogels based on (AB)n-segmented copolymers with polyethylene glycol segments for biofabrication

Tuesday (17.03.2020)
17:58 - 18:01

The combination of bioprinting and additive manufacturing of a supporting polymer construct is a promising approach in the area of biofabrication to tailor the mechanical properties, enhance the structural integrity and improve the cell encapsulation of the employed low viscosity bioinks.1 Up to now, reported supporting materials are either hydrophobic semi-crystalline polymers with opaque properties, such as poly(ε-caprolactone) or materials which are chemically crosslinked after the printing process.2,3 There is a need for new polymers which can be processed from the melt with additive manufacturing techniques like extrusion-based 3D printing or melt electrowriting (MEW) and swell in aqueous media to hydrogels with adjustable mechanical properties.

Herein, we report the development of tailored (AB)n-segmented copolymers designed with polyethylene glycol (PEG) soft segments and thermoreversible physically crosslinked bisurea hard segments with n repeating units. The polymers were synthesized by step-growth polymerization from amino-terminated PEG (Jeffamine®, ED-900 g/mol) and either hexamethylene (HM) or 4,4’-methylene-bis(cyclohexyl) (mbCH) diisocyanate. The polymerization degree n was regulated by the addition of the monofunctional n-butylamine as terminating reagent in various equivalencies. Polymers with mbCH hard segments do not dissolve in aqueous media, but form stable hydrogels. Polymers with HM hard segments first swell but later slowly dissolve completely in aqueous media. We successfully prepared 3D scaffolds by both MEW and extrusion-based 3D printing. We see applications of these polymers as scaffolds or for the assembly of bioinks which will extend the biofabrication processing window.

 

 

 

1. Malda J.; Adv. Mater., 2013, 25, 5011.

2. Brown T.D.; Adv. Mater., 2011, 23,5651.

3. Chen F.; Biomacromolecules, 2016, 17, 208.

Speaker:
Andreas Frank
University of Bayreuth
Additional Authors:
  • Jannik Mechau
    University of Bayreuth
  • Ezgi Bakirci
    University Hospital Würzburg
  • Simon Gumbel
    University of Bayreuth
  • Dr. Reiner Giesa
    University of Bayreuth
  • Prof. Dr. Jürgen Groll
    University Hospital Würzburg
  • Prof. Dr. Paul D. Dalton
    University Hospital Würzburg
  • Prof. Dr. Hans-Werner Schmidt
    University of Bayreuth