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Special Poster Session Biofabrication

Hydrogels based on (AB)n-segmented copolymers with polyethylene glycol segments for biofabrication

Tuesday (17.03.2020)
17:58 - 18:01
Part of:
Line-Up:
17:40 Special Poster Session Biofabrication Hyaluronan based dual-stage crosslinking approach for 3D bioprinting of mesenchymal stem cells 1 Leonard Forster
17:43 Special Poster Session Biofabrication Cell-loaded Microgels as mechanical Protection and controlled Microenvironment for Cells in Bioinks 1 Ilona Paulus
17:46 Special Poster Session Biofabrication Poly(2-oxazoline)/poly(2-oxazine) copolymers: From thermoresponsive hydrogels towards functional bioink formulations 1 Lukas Hahn
17:49 Special Poster Session Biofabrication Glycoengineering as a tool to control the behavior of bone marrow-derived mesenchymal stromal cells in biofabrication processes 1 Stephan Altmann
17:52 Special Poster Session Biofabrication Fiber reinforced hydrogels – a new platform technology in biofabrication 1 Dipl.-Ing. David Sonnleitner
17:55 Special Poster Session Biofabrication 3D Bioprinting of Multicellular Adipose-derived Stromal Cell Spheroids in Hyaluronic Acid-based Bioinks 1 Hannes Horder
17:58 Special Poster Session Biofabrication Hydrogels based on (AB)n-segmented copolymers with polyethylene glycol segments for biofabrication 1 Andreas Frank
18:01 Special Poster Session Biofabrication Metabolic glycoengineering and bioinks 1 Jürgen Mut
18:04 Special Poster Session Biofabrication Improved Printability of a Novel Thermoresponsive Hydrogel Bioink by Nanoclay Addition 1 Ph.D. Chen Hu
18:07 Special Poster Session Biofabrication 3D Printing of Vascular Structures from Vascular Wall-Resident Stem Cells 1 Dr. Leyla Dogan
18:10 Special Poster Session Biofabrication Simultaneous printing of skeletal muscle tissue models and customized bioreactor 1 Dipl.-Ing. Claudia Müller
18:13 Special Poster Session Biofabrication Multiphoton Microscopy: A Powerful Tool to Reveal Cellular Organization and Morphollogy within Bioengineered Constructs in 3D 1 Dipl.-Ing. Dominik Schneidereit
18:16 Special Poster Session Biofabrication Evaluation of inkjet printing for ADA-PEG bioinks 1 Ph.D. Emine Karakaya
18:19 Special Poster Session Biofabrication Establishment of a fiber-based and RGD-modified spider silk for the generation of a drug-producing tissue container 1 Dr. Dominik Steiner
18:22 Special Poster Session Biofabrication 4D Biofabrication of Skeletal Muscle Microtissue Using Electrospun Bilayers 2 Indra Apsite

Session S.1: Special Poster Session Biofabrication Session 1
Belongs to:
General Topic S: Special Poster Session Biofabrication


The combination of bioprinting and additive manufacturing of a supporting polymer construct is a promising approach in the area of biofabrication to tailor the mechanical properties, enhance the structural integrity and improve the cell encapsulation of the employed low viscosity bioinks.1 Up to now, reported supporting materials are either hydrophobic semi-crystalline polymers with opaque properties, such as poly(ε-caprolactone) or materials which are chemically crosslinked after the printing process.2,3 There is a need for new polymers which can be processed from the melt with additive manufacturing techniques like extrusion-based 3D printing or melt electrowriting (MEW) and swell in aqueous media to hydrogels with adjustable mechanical properties.

Herein, we report the development of tailored (AB)n-segmented copolymers designed with polyethylene glycol (PEG) soft segments and thermoreversible physically crosslinked bisurea hard segments with n repeating units. The polymers were synthesized by step-growth polymerization from amino-terminated PEG (Jeffamine®, ED-900 g/mol) and either hexamethylene (HM) or 4,4’-methylene-bis(cyclohexyl) (mbCH) diisocyanate. The polymerization degree n was regulated by the addition of the monofunctional n-butylamine as terminating reagent in various equivalencies. Polymers with mbCH hard segments do not dissolve in aqueous media, but form stable hydrogels. Polymers with HM hard segments first swell but later slowly dissolve completely in aqueous media. We successfully prepared 3D scaffolds by both MEW and extrusion-based 3D printing. We see applications of these polymers as scaffolds or for the assembly of bioinks which will extend the biofabrication processing window.




1. Malda J.; Adv. Mater., 2013, 25, 5011.

2. Brown T.D.; Adv. Mater., 2011, 23,5651.

3. Chen F.; Biomacromolecules, 2016, 17, 208.

 

Speaker:
Andreas Frank
University of Bayreuth
Additional Authors:
  • Jannik Mechau
    University of Bayreuth
  • Ezgi Bakirci
    University Hospital Würzburg
  • Simon Gumbel
    University of Bayreuth
  • Dr. Reiner Giesa
    University of Bayreuth
  • Prof. Dr. Jürgen Groll
    University Hospital Würzburg
  • Prof. Dr. Paul D. Dalton
    University Hospital Würzburg
  • Prof. Dr. Hans-Werner Schmidt
    University of Bayreuth