Programme

Unfurtunately the monastery Irsee has been closed by the Bavarian government due to the corona virus.

Therefore we have decided to offer the conference as a web conference only.

In those unpredictable times, protecting our participants’ health has the highest priority for us!

The scientific exchange must not come to a complete standstill and we believe that with this web solution we have found a way to keep the scientific community going.

In order to participate in the livestream of the conference as easy as possible and to give your presentation, we recommend the use of the web browsers Google Chrome or Microsoft Edge.

Here you can find detailed instructions for using the livestream.

As a participant of the Bioinspired 2020 you have received an e-mail containing the login data for the web conference.

The login data for the sessions are provided daily.

In order to allow all conference participants access to the posters, we ask you to upload your poster by login on the conference homepage and clicking on the button "My Submission" in the upper right corner of the conference homepage. Then select the submission to which you want to upload the poster and upload the poster at the bottom of the page.

Furthermore we would like to ask all poster authors to prepare 4 PowerPoint slides to present your poster to the audience.
Please also include your contact details on the digital poster to allow participants to reach you with questions.

Please note that your poster will be pictured publically.

As poster author you can upload your poster similar to the way you submitted your abstract.
Click on "My Submissions" in the upper right corner at the homepage.

Poster documents can be found by opening the respective abstract in the online programme.
If a poster document has already been uploaded for the abstract, it can then be opened and downloaded.

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Please use for this the Q&A (F&A) button!

For further scientific exchange we implemented a discussion forum on the homepage of the DGM.
Please visit discussion.dgm.de and use your DGM or Bioinspired user credentials to login.

Back to overview

Keynote

Designing New Bioinspired 3D Hydrogels for Tissue Regeneration

Tuesday (17.03.2020)
11:00 - 11:30

Molecular self-assembly is a key direction in current nanotechnology based material science fields. In this approach, the physical properties of the formed assemblies are directed by the inherent characteristics of the specific building blocks used. Molecular co-assembly at varied stoichiometry substantially increases the structural and functional diversity of the formed assemblies, thus allowing tuning of both their architecture as well as their physical properties.

In particular, building blocks of short peptides and amino acids can form ordered assemblies such as nanotubes, nanospheres and 3D-hydrogels. These assemblies were shown to have unique mechanical, optical, piezoelectric and semiconductive properties. Yet, the control over the physical properties of the structure has remained challenging. For example, controlling nanotube length in solution is difficult, due to the inherent sequential self-assembly mechanism. Another example is the control of 3D-hydrogel scaffold’s physical properties, including mechanical strength, degradation profile and injectability, which are important for tissue engineering applications.

Here, in line with polymer chemistry paradigms, we applied a supramolecular polymer co-assembly methodology to modulate the physical properties of peptide nanotubes and hydrogel scaffolds. Utilizing this approach with peptide nanotubes, we achieved narrow nanotube length distribution by adjusting the molecular ratio between the two building blocks; the diphenylalanine assembly unit and its end-capped analogue. In addition, applying a co-assembly approach on hydrogel forming peptides resulted in a synergistic modulation of the mechanical properties, forming extraordinary rigid hydrogels. Furthermore, we designed organic-inorganic scaffold for bone tissue regeneration.

This work provides a conceptual framework for the utilization of co-assembly strategies to push the limits of nanostructures physical properties obtained through self-assembly.   

 

References

  1. Ghosh, M.; Halperin-Sternfeld, M.; Grinberg, I.; Adler-Abramovich, L. Nanomaterials 2019, 9, (4), 497.
  2. Aviv, M.; Halperin-Sternfeld, M.; Grigoriants, I.; Buzhansky, L.; Mironi-Harpaz, I.; Seliktar, D.; Einav, S.; Nevo, Z.; Adler-Abramovich, L. ACS Appl. Mater. Interfaces 2018, 10, (49), 41883-41891.
  3. Halperin-Sternfeld, M.; Ghosh, M.; Sevostianov, R.; Grogoriants, I.; Adler-Abramovich, L. Chem. Comm. 2017, 53, 9586-9589.
  4. Ghosh, M.; Halperin-Sternfeld, M.; Grigoriants, I.; Lee, J.; Nam, K. T.; Adler-Abramovich, L. Biomacromolecules 2017, 18, (11), 3541-3550.
Speaker:
Dr. Lihi Adler-Abramovich
Tel Aviv University