Programme

Unfurtunately the monastery Irsee has been closed by the Bavarian government due to the corona virus.

Therefore we have decided to offer the conference as a web conference only.

In those unpredictable times, protecting our participants’ health has the highest priority for us!

The scientific exchange must not come to a complete standstill and we believe that with this web solution we have found a way to keep the scientific community going.

In order to participate in the livestream of the conference as easy as possible and to give your presentation, we recommend the use of the web browsers Google Chrome or Microsoft Edge.

Here you can find detailed instructions for using the livestream.

As a participant of the Bioinspired 2020 you have received an e-mail containing the login data for the web conference.

The login data for the sessions are provided daily.

In order to allow all conference participants access to the posters, we ask you to upload your poster by login on the conference homepage and clicking on the button "My Submission" in the upper right corner of the conference homepage. Then select the submission to which you want to upload the poster and upload the poster at the bottom of the page.

Furthermore we would like to ask all poster authors to prepare 4 PowerPoint slides to present your poster to the audience.
Please also include your contact details on the digital poster to allow participants to reach you with questions.

Please note that your poster will be pictured publically.

As poster author you can upload your poster similar to the way you submitted your abstract.
Click on "My Submissions" in the upper right corner at the homepage.

Poster documents can be found by opening the respective abstract in the online programme.
If a poster document has already been uploaded for the abstract, it can then be opened and downloaded.

Please note that your poster will be pictured publically.

You can ask your questions via chat already during the presentations!
Please use for this the Q&A (F&A) button!

For further scientific exchange we implemented a discussion forum on the homepage of the DGM.
Please visit discussion.dgm.de and use your DGM or Bioinspired user credentials to login.

Back to overview

Keynote

Synthetic building blocks to direct cells

Monday (16.03.2020)
14:10 - 14:40

We apply polymeric molecular and nano to micron scale building blocks to assemble soft 3D biomimetic constructs, which allow studying and controlling cell/material interactions. Hybrid artificial biomaterial matrices are created with anisotropic and dynamic properties. Microgels and fibers are produced by adapted technologies based on fiber spinning, microfluidics, and in mold polymerization. To arrange the building blocks in a spatially controlled manner, we rely on self assembly mechanisms and assembly by external magnetic fields. One of the new material platforms we developed is the Anisogel. It offers a solution for the particular challenge of regenerating sensitive tissues with an oriented architecture, which require a low invasive therapy. The Anisogel can be injected as a liquid and structured in situ in a controlled manner with defined biochemical, mechanical, and structural parameter. Magnetoceptive, anisometric microgels or short fibers are incorporated as building blocks to create a unidirectional structure. Cells and nerves grow in a linear manner and the fibronectin produced by fibroblasts is aligned. RGD modification of the microgels further improves the orientation of the cells but significantly reduces fibronectin production. The mechano sensitive protein yes associated protein shuttles to the nucleus due to the mechanical ani sotropy of the Anisogel. Regenerated nerves are functional with spontaneous activity and electrical signals propagating along the anisotropy axis of the material. Another developed platform is a thermoresponsive hydrogel system, encapsulated with plasmonic gold nanorods, to control and vary the mechanical properties of the gel in a dynamic and reversible manner using light. This system elucidates how rapid mechanical transitions lead to nuclear translocation of the protein myocardin related transcription f actor A, depending on the ampli tude and frequency of actuation.


1. J. Rose, L. De Laporte. Advanced Healthcare Materials 2018, 7(6):e1701067.
2. L.P.B. Guerzoni, J. Bohl, A. Jans, J.C. Rose, J. Köhler, A.J.C. Kuehne, L. De Laporte L. Biomaterials Science. 2017, 5(8): 1549-57.
3. L.P.B. Guerzoni, A. Jans, D.B. Gehlen, J. Rose, T. Haraszti, Wessling M, Kuehne AJC, De Laporte L. Small 2019, e1900692.
4. L.P.B. Guerzoni, Y. Tsukamoto, M. Akashi, L. De Laporte. A Layer-by-layer single-cell coating technique to produce injectable mini heart tissues via microfluidics. Biomacromolecules. 2019, Available online.
5. J.C. Rose, M. Cámara-Torres, K. Rahimi, J. Köhler, M. Möller, L. De Laporte. Nano Letters, 2017, 17(6): 3782-91.
6. J.C. Rose, D.B. Gehlen, T. Haraszti, J. Köhler, C.J. Licht, L. De Laporte. Biomaterials 2018, 163:128-41.
7. A. Omidinia-Anarkoli, S. Boesveld, U. Tuvshindorj, J. Rose, T. Haraszti, L. De Laporte. Small 2017, 13(36).
8. A. Omidinia-Anarkoli, R. Rimal, Y. Chandorkar, D. Gehlen, J.C. Rose, K. Rahimi, L. De Laporte. ACS Applied Materials and Interfaces 2019, 11(8): 7671-85.
9. Y. Chandorkar, A. Castro Nava, H. Zhang, S. Schweizerhof, M. van Dongen, T. Haraszti, J. Köhler, H. Zhang, R. Windoffer, A. Mourran, M. Möller, L. De Laporte. Nature Communications. 2019 Sep 6;10(1):4027.

Speaker:
Prof. Dr. Laura De Laporte
DWI - Leibniz Institute for Interactive Materials